398.0K XNAS Volume
XNAS 20 Mar, 2025 1:16 PM (EDT)
| Client Name | Client Category | Action | Reported to Exchange | Quantity | Post Transaction Holding | Traded % | Avg. Price | Value | Security Type |
|---|---|---|---|---|---|---|---|---|---|
| Kevin C. Gorman | Director | Sale of securities on an exchange or to another person at price $ 116.68 per share. | 13 Feb 2025 | 3,012 | 524,209 (0%) | 0% | 116.7 | 351,450 | Common Stock |
| Kevin C. Gorman | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 13 Feb 2025 | 5,603 | 16,812 | - | - | Restricted Stock Unit | |
| Kevin C. Gorman | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 13 Feb 2025 | 5,376 | 10,754 | - | - | Restricted Stock Unit | |
| Kevin C. Gorman | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 13 Feb 2025 | 5,376 | 524,450 (0%) | 0% | 0 | Common Stock | |
| Kevin C. Gorman | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 13 Feb 2025 | 5,603 | 527,221 (0%) | 0% | 0 | Common Stock | |
| Kevin C. Gorman | Director | Sale of securities on an exchange or to another person at price $ 116.69 per share. | 13 Feb 2025 | 2,832 | 521,618 (0%) | 0% | 116.7 | 330,465 | Common Stock |
| Stephen A. Sherwin | Director | Sale of securities on an exchange or to another person at price $ 116.69 per share. | 13 Feb 2025 | 13,831 | 10,673 (0%) | 0% | 116.7 | 1,613,923 | Common Stock |
| Eric S. Benevich | Chief Commercial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 12 Feb 2025 | 2,083 | 44,882 (0%) | 0% | 0 | Common Stock | |
| Eric S. Benevich | Chief Commercial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 12 Feb 2025 | 1,961 | 5,885 | - | - | Restricted Stock Unit | |
| Eric S. Benevich | Chief Commercial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 12 Feb 2025 | 2,083 | 4,166 | - | - | Restricted Stock Unit | |
| Eric S. Benevich | Chief Commercial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 12 Feb 2025 | 8,022 | 8,022 | - | - | Restricted Stock Unit | |
| Eric S. Benevich | Chief Commercial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 12 Feb 2025 | 42,805 | 42,805 | - | - | Stock Option | |
| Eric S. Benevich | Chief Commercial Officer | Sale of securities on an exchange or to another person at price $ 116.71 per share. | 12 Feb 2025 | 1,056 | 44,689 (0%) | 0% | 116.7 | 123,245 | Common Stock |
| Eric S. Benevich | Chief Commercial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 12 Feb 2025 | 1,961 | 45,745 (0%) | 0% | 0 | Common Stock | |
| Eric S. Benevich | Chief Commercial Officer | Sale of securities on an exchange or to another person at price $ 116.74 per share. | 12 Feb 2025 | 1,098 | 43,784 (0%) | 0% | 116.7 | 128,183 | Common Stock |
| Darin M. Lippoldt | Chief Legal Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 12 Feb 2025 | 2,017 | 44,491 (0%) | 0% | 0 | Common Stock | |
| Darin M. Lippoldt | Chief Legal Officer | Sale of securities on an exchange or to another person at price $ 116.76 per share. | 12 Feb 2025 | 1,098 | 42,474 (0%) | 0% | 116.8 | 128,202 | Common Stock |
| Darin M. Lippoldt | Chief Legal Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 12 Feb 2025 | 2,083 | 43,572 (0%) | 0% | 0 | Common Stock | |
| Darin M. Lippoldt | Chief Legal Officer | Gift of securities by or to the insider at price $ 0.00 per share. | 12 Feb 2025 | 190 | 41,489 (0%) | 0% | 0 | Common Stock | |
| Darin M. Lippoldt | Chief Legal Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 12 Feb 2025 | 2,017 | 6,053 | - | - | Restricted Stock Unit | |
| Darin M. Lippoldt | Chief Legal Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 12 Feb 2025 | 2,083 | 4,166 | - | - | Restricted Stock Unit | |
| Darin M. Lippoldt | Chief Legal Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 12 Feb 2025 | 7,169 | 7,169 | - | - | Restricted Stock Unit | |
| Darin M. Lippoldt | Chief Legal Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 12 Feb 2025 | 38,252 | 38,252 | - | - | Stock Option | |
| Darin M. Lippoldt | Chief Legal Officer | Sale of securities on an exchange or to another person at price $ 116.75 per share. | 12 Feb 2025 | 1,086 | 43,405 (0%) | 0% | 116.7 | 126,790 | Common Stock |
| Kyle W. Gano | Director, Chief Executive Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 12 Feb 2025 | 104,736 | 104,736 | - | - | Stock Option | |
| Kyle W. Gano | Director, Chief Executive Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 12 Feb 2025 | 2,241 | 141,113 (0%) | 0% | 0 | Common Stock | |
| Kyle W. Gano | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 116.84 per share. | 12 Feb 2025 | 1,352 | 138,872 (0%) | 0% | 116.8 | 157,974 | Common Stock |
| Kyle W. Gano | Director, Chief Executive Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 12 Feb 2025 | 2,566 | 140,224 (0%) | 0% | 0 | Common Stock | |
| Kyle W. Gano | Director, Chief Executive Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 12 Feb 2025 | 2,241 | 6,725 | - | - | Restricted Stock Unit | |
| Kyle W. Gano | Director, Chief Executive Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 12 Feb 2025 | 2,566 | 5,132 | - | - | Restricted Stock Unit | |
| Kyle W. Gano | Director, Chief Executive Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 12 Feb 2025 | 19,628 | 19,628 | - | - | Restricted Stock Unit | |
| Kyle W. Gano | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 116.86 per share. | 12 Feb 2025 | 1,206 | 139,907 (0%) | 0% | 116.9 | 140,934 | Common Stock |
| Matthew C. Abernethy | Chief Financial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 12 Feb 2025 | 45,538 | 45,538 | - | - | Stock Option | |
| Matthew C. Abernethy | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 12 Feb 2025 | 2,241 | 37,016 (0%) | 0% | 0 | Common Stock | |
| Matthew C. Abernethy | Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 116.85 per share. | 12 Feb 2025 | 1,352 | 34,775 (0%) | 0% | 116.8 | 157,979 | Common Stock |
| Matthew C. Abernethy | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 12 Feb 2025 | 2,566 | 36,127 (0%) | 0% | 0 | Common Stock | |
| Matthew C. Abernethy | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 12 Feb 2025 | 2,241 | 6,725 | - | - | Restricted Stock Unit | |
| Matthew C. Abernethy | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 12 Feb 2025 | 2,566 | 5,132 | - | - | Restricted Stock Unit | |
| Matthew C. Abernethy | Chief Financial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 12 Feb 2025 | 8,534 | 8,534 | - | - | Restricted Stock Unit | |
| Matthew C. Abernethy | Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 116.87 per share. | 12 Feb 2025 | 1,206 | 35,810 (0%) | 0% | 116.9 | 140,944 | Common Stock |
| Eiry W. Roberts | Chief Medical Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 12 Feb 2025 | 1,372 | 36,140 (0%) | 0% | 0 | Common Stock | |
| Eiry W. Roberts | Chief Medical Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 12 Feb 2025 | 1,120 | 35,372 (0%) | 0% | 0 | Common Stock | |
| Eiry W. Roberts | Chief Medical Officer | Sale of securities on an exchange or to another person at price $ 116.90 per share. | 12 Feb 2025 | 1,114 | 34,252 (0%) | 0% | 116.9 | 130,232 | Common Stock |
| Eiry W. Roberts | Chief Medical Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 12 Feb 2025 | 2,113 | 35,366 (0%) | 0% | 0 | Common Stock | |
| Eiry W. Roberts | Chief Medical Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 12 Feb 2025 | 1,372 | 4,115 | - | - | Restricted Stock Unit | |
| Eiry W. Roberts | Chief Medical Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 12 Feb 2025 | 1,120 | 3,363 | - | - | Restricted Stock Unit | |
| Eiry W. Roberts | Chief Medical Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 12 Feb 2025 | 2,113 | 4,227 | - | - | Restricted Stock Unit | |
| Eiry W. Roberts | Chief Medical Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 12 Feb 2025 | 8,108 | 8,108 | - | - | Restricted Stock Unit | |
| Eiry W. Roberts | Chief Medical Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 12 Feb 2025 | 43,261 | 43,261 | - | - | Stock Option | |
| Eiry W. Roberts | Chief Medical Officer | Sale of securities on an exchange or to another person at price $ 115.04 per share. | 12 Feb 2025 | 500 | 35,640 (0%) | 0% | 115.0 | 57,521 | Common Stock |
| Eiry W. Roberts | Chief Medical Officer | Sale of securities on an exchange or to another person at price $ 116.74 per share. | 12 Feb 2025 | 604 | 34,768 (0%) | 0% | 116.7 | 70,510 | Common Stock |
| Julie S. Cooke | Chief Human Resources Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 12 Feb 2025 | 1,401 | 4,203 | - | - | Restricted Stock Unit | |
| Julie S. Cooke | Chief Human Resources Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 12 Feb 2025 | 1,509 | 20,340 (0%) | 0% | 0 | Common Stock | |
| Julie S. Cooke | Chief Human Resources Officer | Sale of securities on an exchange or to another person at price $ 116.77 per share. | 12 Feb 2025 | 796 | 19,544 (0%) | 0% | 116.8 | 92,946 | Common Stock |
| Julie S. Cooke | Chief Human Resources Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 12 Feb 2025 | 1,401 | 20,945 (0%) | 0% | 0 | Common Stock | |
| Julie S. Cooke | Chief Human Resources Officer | Sale of securities on an exchange or to another person at price $ 116.80 per share. | 12 Feb 2025 | 755 | 20,190 (0%) | 0% | 116.8 | 88,183 | Common Stock |
| Julie S. Cooke | Chief Human Resources Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 12 Feb 2025 | 29,600 | 29,600 | - | - | Stock Option | |
| Julie S. Cooke | Chief Human Resources Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 12 Feb 2025 | 5,548 | 5,548 | - | - | Restricted Stock Unit | |
| Julie S. Cooke | Chief Human Resources Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 12 Feb 2025 | 1,509 | 3,020 | - | - | Restricted Stock Unit | |
| David W. Boyer | Chief Corp. Affairs Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 12 Feb 2025 | 1,541 | 4,624 | - | - | Restricted Stock Unit | |
| David W. Boyer | Chief Corp. Affairs Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 12 Feb 2025 | 1,811 | 3,623 | - | - | Restricted Stock Unit | |
| David W. Boyer | Chief Corp. Affairs Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 12 Feb 2025 | 34,153 | 34,153 | - | - | Stock Option | |
| David W. Boyer | Chief Corp. Affairs Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 12 Feb 2025 | 6,401 | 6,401 | - | - | Restricted Stock Unit | |
| David W. Boyer | Chief Corp. Affairs Officer | Sale of securities on an exchange or to another person at price $ 116.69 per share. | 12 Feb 2025 | 830 | 3,565 (0%) | 0% | 116.7 | 96,849 | Common Stock |
| David W. Boyer | Chief Corp. Affairs Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 12 Feb 2025 | 1,541 | 4,395 (0%) | 0% | 0 | Common Stock | |
| David W. Boyer | Chief Corp. Affairs Officer | Sale of securities on an exchange or to another person at price $ 116.79 per share. | 12 Feb 2025 | 955 | 2,854 (0%) | 0% | 116.8 | 111,538 | Common Stock |
| David W. Boyer | Chief Corp. Affairs Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 12 Feb 2025 | 1,811 | 3,809 (0%) | 0% | 0 | Common Stock | |
| Jude Onyia | Chief Scientific Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 12 Feb 2025 | 2,717 | 18,278 (0%) | 0% | 0 | Common Stock | |
| Jude Onyia | Chief Scientific Officer | Sale of securities on an exchange or to another person at price $ 116.83 per share. | 12 Feb 2025 | 1,432 | 16,846 (0%) | 0% | 116.8 | 167,306 | Common Stock |
| Jude Onyia | Chief Scientific Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 12 Feb 2025 | 2,690 | 19,536 (0%) | 0% | 0 | Common Stock | |
| Jude Onyia | Chief Scientific Officer | Sale of securities on an exchange or to another person at price $ 116.75 per share. | 12 Feb 2025 | 1,447 | 18,089 (0%) | 0% | 116.7 | 168,933 | Common Stock |
| Jude Onyia | Chief Scientific Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 12 Feb 2025 | 54,645 | 54,645 | - | - | Stock Option | |
| Jude Onyia | Chief Scientific Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 12 Feb 2025 | 10,241 | 10,241 | - | - | Restricted Stock Unit | |
| Jude Onyia | Chief Scientific Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 12 Feb 2025 | 2,717 | 5,434 | - | - | Restricted Stock Unit | |
| Jude Onyia | Chief Scientific Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 12 Feb 2025 | 2,690 | 8,070 | - | - | Restricted Stock Unit | |
| Ingrid Delaet | Chief Regulatory Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 12 Feb 2025 | 1,401 | 5,485 (0%) | 0% | 0 | Common Stock | |
| Ingrid Delaet | Chief Regulatory Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 12 Feb 2025 | 1,358 | 4,800 (0%) | 0% | 0 | Common Stock | |
| Ingrid Delaet | Chief Regulatory Officer | Sale of securities on an exchange or to another person at price $ 116.69 per share. | 12 Feb 2025 | 716 | 4,084 (0%) | 0% | 116.7 | 83,549 | Common Stock |
| Ingrid Delaet | Chief Regulatory Officer | Sale of securities on an exchange or to another person at price $ 116.72 per share. | 12 Feb 2025 | 755 | 4,730 (0%) | 0% | 116.7 | 88,125 | Common Stock |
| Ingrid Delaet | Chief Regulatory Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 12 Feb 2025 | 34,153 | 34,153 | - | - | Stock Option | |
| Ingrid Delaet | Chief Regulatory Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 12 Feb 2025 | 6,401 | 6,401 | - | - | Restricted Stock Unit | |
| Ingrid Delaet | Chief Regulatory Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 12 Feb 2025 | 1,358 | 2,718 | - | - | Restricted Stock Unit | |
| Ingrid Delaet | Chief Regulatory Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 12 Feb 2025 | 1,401 | 4,203 | - | - | Restricted Stock Unit | |
| Kevin C. Gorman | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 08 Feb 2025 | 4,318 | 521,348 (0%) | 0% | 0 | Common Stock | |
| Kevin C. Gorman | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 08 Feb 2025 | 4,318 | 0 | - | - | Restricted Stock Unit | |
| Kevin C. Gorman | Director | Sale of securities on an exchange or to another person at price $ 118.37 per share. | 08 Feb 2025 | 2,274 | 519,074 (0%) | 0% | 118.4 | 269,167 | Common Stock |
| Eric S. Benevich | Chief Commercial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 08 Feb 2025 | 1,860 | 0 | - | - | Restricted Stock Unit | |
| Eric S. Benevich | Chief Commercial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 08 Feb 2025 | 1,860 | 43,779 (0%) | 0% | 0 | Common Stock | |
| Eric S. Benevich | Chief Commercial Officer | Sale of securities on an exchange or to another person at price $ 118.31 per share. | 08 Feb 2025 | 980 | 42,799 (0%) | 0% | 118.3 | 115,940 | Common Stock |
| Darin M. Lippoldt | Chief Legal Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 08 Feb 2025 | 1,727 | 0 | - | - | Restricted Stock Unit | |
| Darin M. Lippoldt | Chief Legal Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 08 Feb 2025 | 1,727 | 42,590 (0%) | 0% | 0 | Common Stock | |
| Darin M. Lippoldt | Chief Legal Officer | Sale of securities on an exchange or to another person at price $ 118.25 per share. | 08 Feb 2025 | 911 | 41,679 (0%) | 0% | 118.3 | 107,727 | Common Stock |
| Kyle W. Gano | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 118.39 per share. | 08 Feb 2025 | 980 | 137,658 (0%) | 0% | 118.4 | 116,020 | Common Stock |
| Kyle W. Gano | Director, Chief Executive Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 08 Feb 2025 | 1,860 | 138,638 (0%) | 0% | 0 | Common Stock | |
| Kyle W. Gano | Director, Chief Executive Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 08 Feb 2025 | 1,860 | 0 | - | - | Restricted Stock Unit | |
| Matthew C. Abernethy | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 08 Feb 2025 | 1,860 | 0 | - | - | Restricted Stock Unit | |
| Matthew C. Abernethy | Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 118.27 per share. | 08 Feb 2025 | 980 | 33,561 (0%) | 0% | 118.3 | 115,909 | Common Stock |
| Matthew C. Abernethy | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 08 Feb 2025 | 1,860 | 34,541 (0%) | 0% | 0 | Common Stock | |
| Eiry W. Roberts | Chief Medical Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 08 Feb 2025 | 1,860 | 0 | - | - | Restricted Stock Unit | |
| Eiry W. Roberts | Chief Medical Officer | Sale of securities on an exchange or to another person at price $ 118.22 per share. | 08 Feb 2025 | 980 | 33,253 (0%) | 0% | 118.2 | 115,853 | Common Stock |
| Eiry W. Roberts | Chief Medical Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 08 Feb 2025 | 1,860 | 34,233 (0%) | 0% | 0 | Common Stock | |
| Julie S. Cooke | Chief Human Resources Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 08 Feb 2025 | 1,329 | 19,531 (0%) | 0% | 0 | Common Stock | |
| Julie S. Cooke | Chief Human Resources Officer | Sale of securities on an exchange or to another person at price $ 118.28 per share. | 08 Feb 2025 | 700 | 18,831 (0%) | 0% | 118.3 | 82,793 | Common Stock |
| Julie S. Cooke | Chief Human Resources Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 08 Feb 2025 | 1,329 | 0 | - | - | Restricted Stock Unit | |
| David W. Boyer | Chief Corp. Affairs Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 08 Feb 2025 | 1,329 | 2,698 (0%) | 0% | 0 | Common Stock | |
| David W. Boyer | Chief Corp. Affairs Officer | Sale of securities on an exchange or to another person at price $ 118.31 per share. | 08 Feb 2025 | 700 | 1,998 (0%) | 0% | 118.3 | 82,820 | Common Stock |
| David W. Boyer | Chief Corp. Affairs Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 08 Feb 2025 | 1,329 | 0 | - | - | Restricted Stock Unit | |
| Matthew C. Abernethy | Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 152.87 per share. | 31 Jan 2025 | 1,283 | 32,681 (0%) | 0% | 152.9 | 196,136 | Common Stock |
| Matthew C. Abernethy | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 31 Jan 2025 | 2,436 | 2,437 | - | - | Restricted Stock Unit | |
| Matthew C. Abernethy | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 31 Jan 2025 | 2,436 | 33,964 (0%) | 0% | 0 | Common Stock | |
| Eiry W. Roberts | Chief Medical Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 31 Jan 2025 | 2,769 | 2,769 | - | - | Restricted Stock Unit | |
| Eiry W. Roberts | Chief Medical Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 31 Jan 2025 | 2,769 | 33,830 (0%) | 0% | 0 | Common Stock | |
| Eiry W. Roberts | Chief Medical Officer | Sale of securities on an exchange or to another person at price $ 152.80 per share. | 31 Jan 2025 | 1,457 | 32,373 (0%) | 0% | 152.8 | 222,636 | Common Stock |
| Julie S. Cooke | Chief Human Resources Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 31 Jan 2025 | 1,740 | 19,942 (0%) | 0% | 0 | Common Stock | |
| Julie S. Cooke | Chief Human Resources Officer | Sale of securities on an exchange or to another person at price $ 152.89 per share. | 31 Jan 2025 | 916 | 19,026 (0%) | 0% | 152.9 | 140,045 | Common Stock |
| Julie S. Cooke | Chief Human Resources Officer | Sale of securities on an exchange or to another person at price $ 152.89 per share. | 31 Jan 2025 | 824 | 18,202 (0%) | 0% | 152.9 | 125,980 | Common Stock |
| Julie S. Cooke | Chief Human Resources Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 31 Jan 2025 | 1,740 | 1,741 | - | - | Restricted Stock Unit | |
| David W. Boyer | Chief Corp. Affairs Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 31 Jan 2025 | 2,096 | 2,473 (0%) | 0% | 0 | Common Stock | |
| David W. Boyer | Chief Corp. Affairs Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 31 Jan 2025 | 2,096 | 2,096 | - | - | Restriced Stock Unit | |
| David W. Boyer | Chief Corp. Affairs Officer | Sale of securities on an exchange or to another person at price $ 152.94 per share. | 31 Jan 2025 | 1,104 | 1,369 (0%) | 0% | 152.9 | 168,849 | Common Stock |
| Jude Onyia | Chief Scientific Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 31 Jan 2025 | 238 | 238 | - | - | Restricted Stock Unit | |
| Jude Onyia | Chief Scientific Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 31 Jan 2025 | 238 | 15,687 (0%) | 0% | 0 | Common Stock | |
| Jude Onyia | Chief Scientific Officer | Sale of securities on an exchange or to another person at price $ 152.97 per share. | 31 Jan 2025 | 126 | 15,561 (0%) | 0% | 153.0 | 19,274 | Common Stock |
| Ingrid Delaet | Chief Regulatory Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 31 Jan 2025 | 1,179 | 0 | - | - | Restricted Stock Unit | |
| Ingrid Delaet | Chief Regulatory Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 31 Jan 2025 | 801 | 3,308 (0%) | 0% | 0 | Common Stock | |
| Ingrid Delaet | Chief Regulatory Officer | Sale of securities on an exchange or to another person at price $ 153.05 per share. | 31 Jan 2025 | 422 | 2,886 (0%) | 0% | 153.0 | 64,587 | Common Stock |
| Ingrid Delaet | Chief Regulatory Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 31 Jan 2025 | 1,179 | 4,065 (0%) | 0% | 0 | Common Stock | |
| Ingrid Delaet | Chief Regulatory Officer | Sale of securities on an exchange or to another person at price $ 149.29 per share. | 31 Jan 2025 | 623 | 3,442 (0%) | 0% | 149.3 | 93,008 | Common Stock |
| Ingrid Delaet | Chief Regulatory Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 31 Jan 2025 | 801 | 801 | - | - | Restriced Stock Unit | |
| Kevin C. Gorman | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 31 Jan 2025 | 5,141 | 519,737 (0%) | 0% | 0 | Common Stock | |
| Kevin C. Gorman | Director | Sale of securities on an exchange or to another person at price $ 152.92 per share. | 31 Jan 2025 | 2,707 | 517,030 (0%) | 0% | 152.9 | 413,967 | Common Stock |
| Kevin C. Gorman | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 31 Jan 2025 | 5,141 | 5,142 | - | - | Restricted Stock Unit | |
| Eric S. Benevich | Chief Commercial Officer | Sale of securities on an exchange or to another person at price $ 152.94 per share. | 31 Jan 2025 | 1,207 | 41,919 (0%) | 0% | 152.9 | 184,599 | Common Stock |
| Eric S. Benevich | Chief Commercial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 31 Jan 2025 | 2,294 | 43,126 (0%) | 0% | 0 | Common Stock | |
| Eric S. Benevich | Chief Commercial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 31 Jan 2025 | 2,294 | 2,294 | - | - | Restricted Stock Unit | |
| Darin M. Lippoldt | Chief Legal Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 31 Jan 2025 | 2,373 | 42,113 (0%) | 0% | 0 | Common Stock | |
| Darin M. Lippoldt | Chief Legal Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 31 Jan 2025 | 2,373 | 2,373 | - | - | Restricted Stock Unit | |
| Darin M. Lippoldt | Chief Legal Officer | Sale of securities on an exchange or to another person at price $ 152.91 per share. | 31 Jan 2025 | 1,250 | 40,863 (0%) | 0% | 152.9 | 191,133 | Common Stock |
| Kyle W. Gano | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 152.87 per share. | 31 Jan 2025 | 1,541 | 136,778 (0%) | 0% | 152.9 | 235,577 | Common Stock |
| Kyle W. Gano | Director, Chief Executive Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 31 Jan 2025 | 2,927 | 138,319 (0%) | 0% | 0 | Common Stock | |
| Kyle W. Gano | Director, Chief Executive Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 31 Jan 2025 | 2,927 | 2,927 | - | - | Restricted Stock Unit | |
| Kevin C. Gorman | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 32.99 per share. | 27 Jan 2025 | 146,105 | 660,701 (0%) | 0% | 33.0 | 4,820,004 | Common Stock |
| Kevin C. Gorman | Director | Sale of securities on an exchange or to another person at price $ 149.46 per share. | 27 Jan 2025 | 146,105 | 514,596 (0%) | 0% | 149.5 | 21,836,503 | Common Stock |
| Kevin C. Gorman | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 27 Jan 2025 | 146,105 | 0 | - | - | Non-Qualified Stock Option | |
| Kyle W. Gano | Director, Chief Executive Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 32.99 per share. | 15 Jan 2025 | 4,812 | 140,204 (0%) | 0% | 33.0 | 158,748 | Common Stock |
| Kyle W. Gano | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 141.50 per share. | 15 Jan 2025 | 4,812 | 135,392 (0%) | 0% | 141.5 | 680,894 | Common Stock |
| Kyle W. Gano | Director, Chief Executive Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 32.99 per share. | 15 Jan 2025 | 60,188 | 195,580 (0%) | 0% | 33.0 | 1,985,602 | Common Stock |
| Kyle W. Gano | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 141.50 per share. | 15 Jan 2025 | 60,188 | 135,392 (0%) | 0% | 141.5 | 8,516,656 | Common Stock |
| Kyle W. Gano | Director, Chief Executive Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 15 Jan 2025 | 4,812 | 0 | - | - | Incentive Stock Option | |
| Kyle W. Gano | Director, Chief Executive Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 15 Jan 2025 | 60,188 | 0 | - | - | Non-Qualified Stock Option | |
| Ingrid Delaet | Chief Regulatory Officer | Sale of securities on an exchange or to another person at price $ 138.10 per share. | 31 Dec 2024 | 272 | 2,507 (0%) | 0% | 138.1 | 37,563 | Common Stock |
| Ingrid Delaet | Chief Regulatory Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 79.02 per share. | 31 Dec 2024 | 272 | 2,779 (0%) | 0% | 79.0 | 21,493 | Common Stock |
| Ingrid Delaet | Chief Regulatory Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 31 Dec 2024 | 272 | 2,718 | - | - | Non-Qualified Stock Option | |
| Delaet Ingrid | Chief Regulatory Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 79.02 per share. | 17 Dec 2024 | 1,091 | 3,598 (0%) | 0% | 79.0 | 86,211 | Common Stock |
| Ingrid Delaet | Chief Regulatory Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 17 Dec 2024 | 1,091 | 2,990 | - | - | Non-Qualified Stock Option | |
| Roberts Eiry W. | Chief Medical Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 17 Dec 2024 | 5,487 | 5,487 | - | - | Restricted Stock Unit | |
| W. Roberts Eiry | Chief Medical Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 17 Dec 2024 | 27,770 | 27,770 | - | - | Stock Option | |
| Delaet Ingrid | Chief Regulatory Officer | Sale of securities on an exchange or to another person at price $ 135.00 per share. | 17 Dec 2024 | 1,091 | 2,507 (0%) | 0% | 135 | 147,285 | Common Stock |
| Jude Onyia | Chief Scientific Officer | Sale of securities on an exchange or to another person at price $ 126.29 per share. | 29 Nov 2024 | 2,331 | 15,449 (0%) | 0% | 126.3 | 294,373 | Common Stock |
| Jude Onyia | Chief Scientific Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 29 Nov 2024 | 4,426 | 4,426 | - | - | Restricted Stock Unit | |
| Onyia Jude | Chief Scientific Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 29 Nov 2024 | 4,426 | 17,780 (0%) | 0% | 0 | Common Stock | |
| Eiry W. Roberts | Chief Medical Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 77.81 per share. | 08 Nov 2024 | 5,140 | 28,856 (0%) | 0% | 77.8 | 399,943 | Common Stock |
| Eiry W. Roberts | Chief Medical Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 08 Nov 2024 | 1 | 1,265 | - | - | Incentive Stock Option | |
| Eiry W. Roberts | Chief Medical Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 08 Nov 2024 | 971 | 0 | - | - | Incentive Stock Option | |
| Eiry W. Roberts | Chief Medical Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 08 Nov 2024 | 1,233 | 0 | - | - | Incentive Stock Option | |
| Eiry W. Roberts | Chief Medical Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 08 Nov 2024 | 5,140 | 0 | - | - | Incentive Stock Option | |
| Eiry W. Roberts | Chief Medical Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 79.00 per share. | 08 Nov 2024 | 1 | 31,061 (0%) | 0% | 79 | 79 | Common Stock |
| Eiry W. Roberts | Chief Medical Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 102.90 per share. | 08 Nov 2024 | 971 | 31,060 (0%) | 0% | 102.9 | 99,916 | Common Stock |
| Eiry W. Roberts | Chief Medical Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 81.05 per share. | 08 Nov 2024 | 1,233 | 30,089 (0%) | 0% | 81.1 | 99,935 | Common Stock |
| Stephen A. Sherwin | Director | Gift of securities by or to the insider at price $ 0.00 per share. | 04 Nov 2024 | 2,000 | 24,504 (0%) | 0% | 0 | Common Stock | |
| Kyle W. Gano | Director, Chief Executive Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Nov 2024 | 13,344 | 13,344 | - | - | Stock Option | |
| Kyle W. Gano | Director, Chief Executive Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Nov 2024 | 2,455 | 2,455 | - | - | Restricted Stock Unit | |
| David W. Boyer | Chief Corp. Affairs Officer | Sale of securities on an exchange or to another person at price $ 113.66 per share. | 03 Oct 2024 | 1,295 | 377 (0%) | 0% | 113.7 | 147,190 | Common Stock |
| David W. Boyer | Chief Corp. Affairs Officer | Sale of securities on an exchange or to another person at price $ 121.88 per share. | 13 Sep 2024 | 3,461 | 1,672 (0%) | 0% | 121.9 | 421,828 | Common Stock |
| William H. Rastetter | Director | Sale of securities on an exchange or to another person at price $ 146.69 per share. | 15 Aug 2024 | 14,250 | 37,491 (0%) | 0% | 146.7 | 2,090,333 | Common Stock |
| Gary A. Lyons | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 13 Aug 2024 | 11,570 | 0 | - | - | Non-Qualified Stock Option | |
| Gary A. Lyons | Director | Sale of securities on an exchange or to another person at price $ 150.43 per share. | 13 Aug 2024 | 11,570 | 119,047 (0%) | 0% | 150.4 | 1,740,450 | Common Stock |
| Gary A. Lyons | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 42.76 per share. | 13 Aug 2024 | 11,570 | 130,617 (0%) | 0% | 42.8 | 494,733 | Common Stock |
| Matthew C. Abernethy | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 73.60 per share. | 13 Aug 2024 | 14,100 | 45,628 (0%) | 0% | 73.6 | 1,037,760 | Common Stock |
| Matthew C. Abernethy | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 13 Aug 2024 | 14,100 | 0 | - | - | Non-Qualified Stock Option | |
| Matthew C. Abernethy | Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 150.38 per share. | 13 Aug 2024 | 14,100 | 31,528 (0%) | 0% | 150.4 | 2,120,347 | Common Stock |
| Ingrid Delaet | Chief Regulatory Officer | Sale of securities on an exchange or to another person at price $ 150.13 per share. | 13 Aug 2024 | 3,043 | 6,607 (0%) | 0% | 150.1 | 456,847 | Common Stock |
| Ingrid Delaet | Chief Regulatory Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 13 Aug 2024 | 3,043 | 22,049 | - | - | Non-Qualified Stock Option | |
| Ingrid Delaet | Chief Regulatory Officer | Sale of securities on an exchange or to another person at price $ 150.08 per share. | 13 Aug 2024 | 4,100 | 2,507 (0%) | 0% | 150.1 | 615,333 | Common Stock |
| Ingrid Delaet | Chief Regulatory Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 103.52 per share. | 13 Aug 2024 | 3,043 | 9,650 (0%) | 0% | 103.5 | 315,011 | Common Stock |
| Ingrid Delaet | Chief Regulatory Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 79.02 per share. | 06 Aug 2024 | 273 | 6,880 (0%) | 0% | 79.0 | 21,572 | Common Stock |
| Ingrid Delaet | Chief Regulatory Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 06 Aug 2024 | 273 | 4,081 | - | - | Non-Qualified Stock Option | |
| Ingrid Delaet | Chief Regulatory Officer | Sale of securities on an exchange or to another person at price $ 147.70 per share. | 06 Aug 2024 | 273 | 6,607 (0%) | 0% | 147.7 | 40,322 | Common Stock |
| Darin M. Lippoldt | Chief Legal Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 79.02 per share. | 01 Aug 2024 | 2,996 | 42,736 (0%) | 0% | 79.0 | 236,744 | Common Stock |
| Darin M. Lippoldt | Chief Legal Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 01 Aug 2024 | 2,996 | 43,372 | - | - | Non-Qualified Stock Option | |
| Darin M. Lippoldt | Chief Legal Officer | Sale of securities on an exchange or to another person at price $ 154.01 per share. | 01 Aug 2024 | 2,996 | 39,740 (0%) | 0% | 154.0 | 461,423 | Common Stock |
| Julie S. Cooke | Chief Human Resources Officer | Sale of securities on an exchange or to another person at price $ 153.26 per share. | 01 Aug 2024 | 12,632 | 18,202 (0%) | 0% | 153.3 | 1,936,017 | Common Stock |
| Julie S. Cooke | Chief Human Resources Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 01 Aug 2024 | 12,632 | 0 | - | - | Non-Qualified Stock Option | |
| Julie S. Cooke | Chief Human Resources Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 61.82 per share. | 01 Aug 2024 | 12,632 | 30,834 (0%) | 0% | 61.8 | 780,910 | Common Stock |
| Gary A. Lyons | Director | Sale of securities on an exchange or to another person at price $ 150.03 per share. | 16 Jul 2024 | 930 | 119,047 (0%) | 0% | 150.0 | 139,530 | Common Stock |
| Gary A. Lyons | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 42.76 per share. | 16 Jul 2024 | 930 | 119,977 (0%) | 0% | 42.8 | 39,767 | Common Stock |
| Gary A. Lyons | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 16 Jul 2024 | 930 | 11,570 | - | - | Non-Qualified Stock Option | |
| Darin M. Lippoldt | Chief Legal Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 79.02 per share. | 16 Jul 2024 | 7,004 | 46,744 (0%) | 0% | 79.0 | 553,456 | Common Stock |
| Darin M. Lippoldt | Chief Legal Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 16 Jul 2024 | 7,004 | 46,368 | - | - | Non-Qualified Stock Option | |
| Darin M. Lippoldt | Chief Legal Officer | Sale of securities on an exchange or to another person at price $ 150.00 per share. | 16 Jul 2024 | 7,004 | 39,740 (0%) | 0% | 150.0 | 1,050,590 | Common Stock |
| Matthew C. Abernethy | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 16 Jul 2024 | 900 | 14,100 | - | - | Non-Qualified Stock Option | |
| Matthew C. Abernethy | Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 150.04 per share. | 16 Jul 2024 | 900 | 31,528 (0%) | 0% | 150.0 | 135,037 | Common Stock |
| Matthew C. Abernethy | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 73.60 per share. | 16 Jul 2024 | 900 | 32,428 (0%) | 0% | 73.6 | 66,240 | Common Stock |
| Julie S. Cooke | Chief Human Resources Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 16 Jul 2024 | 900 | 12,632 | - | - | Non-Qualified Stock Option | |
| Julie S. Cooke | Chief Human Resources Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 61.82 per share. | 16 Jul 2024 | 900 | 19,102 (0%) | 0% | 61.8 | 55,638 | Common Stock |
| Julie S. Cooke | Chief Human Resources Officer | Sale of securities on an exchange or to another person at price $ 150.04 per share. | 16 Jul 2024 | 900 | 18,202 (0%) | 0% | 150.0 | 135,036 | Common Stock |
| Ingrid Delaet | Chief Regulatory Officer | Sale of securities on an exchange or to another person at price $ 150.04 per share. | 16 Jul 2024 | 900 | 6,607 (0%) | 0% | 150.0 | 135,036 | Common Stock |
| Ingrid Delaet | Chief Regulatory Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 16 Jul 2024 | 400 | 26,649 | - | - | Non-Qualified Stock Option | |
| Ingrid Delaet | Chief Regulatory Officer | Sale of securities on an exchange or to another person at price $ 150.00 per share. | 16 Jul 2024 | 1,557 | 7,507 (0%) | 0% | 150 | 233,550 | Common Stock |
| Ingrid Delaet | Chief Regulatory Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 103.52 per share. | 16 Jul 2024 | 1,557 | 9,064 (0%) | 0% | 103.5 | 161,181 | Common Stock |
| Ingrid Delaet | Chief Regulatory Officer | Sale of securities on an exchange or to another person at price $ 150.10 per share. | 16 Jul 2024 | 400 | 7,507 (0%) | 0% | 150.1 | 60,041 | Common Stock |
| Ingrid Delaet | Chief Regulatory Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 103.52 per share. | 16 Jul 2024 | 400 | 7,907 (0%) | 0% | 103.5 | 41,408 | Common Stock |
| Ingrid Delaet | Chief Regulatory Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 16 Jul 2024 | 1,557 | 25,092 | - | - | Non-Qualified Stock Option | |
| Julie S. Cooke | Chief Human Resources Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 61.82 per share. | 01 Jul 2024 | 10,000 | 28,202 (0%) | 0% | 61.8 | 618,200 | Common Stock |
| Julie S. Cooke | Chief Human Resources Officer | Sale of securities on an exchange or to another person at price $ 140.19 per share. | 01 Jul 2024 | 10,000 | 18,202 (0%) | 0% | 140.2 | 1,401,864 | Common Stock |
| Julie S. Cooke | Chief Human Resources Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 01 Jul 2024 | 10,000 | 13,532 | - | - | Non-Qualified Stock Option | |
| Ingrid Delaet | Chief Regulatory Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 01 Jul 2024 | 272 | 4,354 | - | - | Non-Qualified Stock Option | |
| Ingrid Delaet | Chief Regulatory Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 79.02 per share. | 01 Jul 2024 | 272 | 7,779 (0%) | 0% | 79.0 | 21,493 | Common Stock |
| Ingrid Delaet | Chief Regulatory Officer | Sale of securities on an exchange or to another person at price $ 138.11 per share. | 01 Jul 2024 | 272 | 7,507 (0%) | 0% | 138.1 | 37,566 | Common Stock |
| Ingrid Delaet | Chief Regulatory Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 79.02 per share. | 31 May 2024 | 273 | 7,780 (0%) | 0% | 79.0 | 21,572 | Common Stock |
| Ingrid Delaet | Chief Regulatory Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 31 May 2024 | 273 | 4,626 | - | - | Non-Qualified Stock Option | |
| Ingrid Delaet | Chief Regulatory Officer | Sale of securities on an exchange or to another person at price $ 136.55 per share. | 31 May 2024 | 273 | 7,507 (0%) | 0% | 136.5 | 37,278 | Common Stock |
| Stephen A. Sherwin | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 29 May 2024 | 25,000 | 0 | - | - | Non-Qualified Stock Option | |
| Stephen A. Sherwin | Director | Sale of securities on an exchange or to another person at price $ 133.47 per share. | 29 May 2024 | 15,000 | 26,504 (0%) | 0% | 133.5 | 2,002,010 | Common Stock |
| Stephen A. Sherwin | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 47.89 per share. | 29 May 2024 | 15,000 | 41,504 (0%) | 0% | 47.9 | 718,350 | Common Stock |
| Stephen A. Sherwin | Director | Sale of securities on an exchange or to another person at price $ 133.46 per share. | 29 May 2024 | 25,000 | 26,504 (0%) | 0% | 133.5 | 3,336,555 | Common Stock |
| Stephen A. Sherwin | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 42.76 per share. | 29 May 2024 | 25,000 | 51,504 (0%) | 0% | 42.8 | 1,069,000 | Common Stock |
| Stephen A. Sherwin | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 29 May 2024 | 15,000 | 0 | - | - | Non-Qualified Stock Option | |
| Gary A. Lyons | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 22 May 2024 | 1,435 | 1,435 | - | - | Restricted Stock Unit | |
| Gary A. Lyons | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 22 May 2024 | 2,982 | 2,982 | - | - | Non-Qualified Stock Option | |
| Richard F. Pops | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 22 May 2024 | 2,869 | 2,869 | - | - | Restricted Stock Unit | |
| Shalini Sharp | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 22 May 2024 | 2,982 | 2,982 | - | - | Non-Qualified Stock Option | |
| Shalini Sharp | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 22 May 2024 | 1,435 | 1,435 | - | - | Restricted Stock Unit | |
| William H. Rastetter | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 22 May 2024 | 2,869 | 2,869 | - | - | Restricted Stock Unit | |
| Christine A. Poon | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 22 May 2024 | 2,982 | 2,982 | - | - | Non-Qualified Stock Option | |
| Christine A. Poon | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 22 May 2024 | 1,435 | 1,435 | - | - | Restricted Stock Unit | |
| George J. Morrow | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 22 May 2024 | 2,869 | 2,869 | - | - | Restricted Stock Unit | |
| Stephen A. Sherwin | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 22 May 2024 | 2,869 | 2,869 | - | - | Restricted Stock Unit | |
| Leslie V. Norwalk | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 22 May 2024 | 2,982 | 2,982 | - | - | Non-Qualified Stock Option | |
| Leslie V. Norwalk | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 22 May 2024 | 1,435 | 1,435 | - | - | Restricted Stock Unit | |
| Johanna Mercier | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 22 May 2024 | 2,982 | 2,982 | - | - | Non-Qualified Stock Option | |
| Johanna Mercier | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 22 May 2024 | 1,435 | 1,435 | - | - | Restricted Stock Unit | |
| Gary A. Lyons | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 17 May 2024 | 2,100 | 119,047 (0%) | 0% | 0 | Common Stock | |
| Gary A. Lyons | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 17 May 2024 | 2,100 | 0 | - | - | Restricted Stock Unit | |
| Richard F. Pops | Director | Sale of securities on an exchange or to another person at price $ 141.84 per share. | 17 May 2024 | 2,100 | 31,611 (0%) | 0% | 141.8 | 297,860 | Common Stock |
| Richard F. Pops | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 17 May 2024 | 4,199 | 33,711 (0%) | 0% | 0 | Common Stock | |
| Richard F. Pops | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 17 May 2024 | 4,199 | 0 | - | - | Restricted Stock Unit | |
| Shalini Sharp | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 17 May 2024 | 2,100 | 0 | - | - | Restricted Stock Unit | |
| Shalini Sharp | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 17 May 2024 | 2,100 | 2,100 (0%) | 0% | 0 | Common Stock | |
| Shalini Sharp | Director | Sale of securities on an exchange or to another person at price $ 141.90 per share. | 17 May 2024 | 1,106 | 994 (0%) | 0% | 141.9 | 156,943 | Common Stock |
| George J. Morrow | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 17 May 2024 | 4,199 | 4,199 (0%) | 0% | 0 | Common Stock | |
| George J. Morrow | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 17 May 2024 | 4,199 | 0 | - | - | Restricted Stock Unit | |
| Stephen A. Sherwin | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 17 May 2024 | 4,199 | 0 | - | - | Restricted Stock Unit | |
| Stephen A. Sherwin | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 17 May 2024 | 4,199 | 26,504 (0%) | 0% | 0 | Common Stock | |
| Johanna Mercier | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 17 May 2024 | 2,100 | 0 | - | - | Restricted Stock Unit | |
| Johanna Mercier | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 17 May 2024 | 2,100 | 2,100 (0%) | 0% | 0 | Common Stock | |
| Gary A. Lyons | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 42.76 per share. | 14 May 2024 | 12,500 | 129,447 (0%) | 0% | 42.8 | 534,500 | Common Stock |
| Gary A. Lyons | Director | Sale of securities on an exchange or to another person at price $ 135.63 per share. | 14 May 2024 | 12,500 | 116,947 (0%) | 0% | 135.6 | 1,695,370 | Common Stock |
| Gary A. Lyons | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 14 May 2024 | 12,500 | 12,500 | - | - | Non-Qualified Stock Option | |
| Matthew C. Abernethy | Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 140.24 per share. | 14 May 2024 | 15,000 | 31,528 (0%) | 0% | 140.2 | 2,103,609 | Common Stock |
| Matthew C. Abernethy | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 73.60 per share. | 14 May 2024 | 15,000 | 46,528 (0%) | 0% | 73.6 | 1,104,000 | Common Stock |
| Matthew C. Abernethy | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 73.60 per share. | 14 May 2024 | 15,000 | 46,528 (0%) | 0% | 73.6 | 1,104,000 | Common Stock |
| Matthew C. Abernethy | Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 135.66 per share. | 14 May 2024 | 15,000 | 31,528 (0%) | 0% | 135.7 | 2,034,827 | Common Stock |
| Matthew C. Abernethy | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 14 May 2024 | 15,000 | 15,000 | - | - | Non-Qualified Stock Option | |
| Matthew C. Abernethy | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 14 May 2024 | 15,000 | 30,000 | - | - | Non-Qualified Stock Option | |
| Ingrid Delaet | Chief Regulatory Officer | Sale of securities on an exchange or to another person at price $ 140.55 per share. | 06 May 2024 | 273 | 7,507 (0%) | 0% | 140.5 | 38,370 | Common Stock |
| Ingrid Delaet | Chief Regulatory Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 06 May 2024 | 273 | 4,899 | - | - | Non-Qualified Stock Option | |
| Ingrid Delaet | Chief Regulatory Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 79.02 per share. | 06 May 2024 | 273 | 7,780 (0%) | 0% | 79.0 | 21,572 | Common Stock |
| Eric S. Benevich | Chief Commercial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 81.49 per share. | 15 Apr 2024 | 7,231 | 48,009 (0%) | 0% | 81.5 | 589,254 | Common Stock |
| Eric S. Benevich | Chief Commercial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 15 Apr 2024 | 7,231 | 26,292 | - | - | Non-Qualified Stock Option | |
| Eric S. Benevich | Chief Commercial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 15 Apr 2024 | 12,587 | 0 | - | - | Non-Qualified Stock Option | |
| Eric S. Benevich | Chief Commercial Officer | Sale of securities on an exchange or to another person at price $ 133.36 per share. | 15 Apr 2024 | 12,587 | 40,778 (0%) | 0% | 133.4 | 1,678,660 | Common Stock |
| Eric S. Benevich | Chief Commercial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 81.05 per share. | 15 Apr 2024 | 12,587 | 53,365 (0%) | 0% | 81.0 | 1,020,176 | Common Stock |
| Eric S. Benevich | Chief Commercial Officer | Sale of securities on an exchange or to another person at price $ 133.36 per share. | 15 Apr 2024 | 7,231 | 40,778 (0%) | 0% | 133.4 | 964,359 | Common Stock |
| Ingrid Delaet | Chief Regulatory Officer | Sale of securities on an exchange or to another person at price $ 137.30 per share. | 01 Apr 2024 | 272 | 7,507 (0%) | 0% | 137.3 | 37,346 | Common Stock |
| Ingrid Delaet | Chief Regulatory Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 01 Apr 2024 | 272 | 5,172 | - | - | Non-Qualified Stock Option | |
| Ingrid Delaet | Chief Regulatory Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 79.02 per share. | 01 Apr 2024 | 272 | 7,779 (0%) | 0% | 79.0 | 21,493 | Common Stock |
| Ingrid Delaet | Chief Regulatory Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 21 Mar 2024 | 5,000 | 27,049 | - | - | Non-Qualified Stock Option | |
| Ingrid Delaet | Chief Regulatory Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 103.52 per share. | 21 Mar 2024 | 5,000 | 12,507 (0%) | 0% | 103.5 | 517,600 | Common Stock |
| Ingrid Delaet | Chief Regulatory Officer | Sale of securities on an exchange or to another person at price $ 145.06 per share. | 21 Mar 2024 | 5,000 | 7,507 (0%) | 0% | 145.1 | 725,320 | Common Stock |
| George J. Morrow | Director | Sale of securities on an exchange or to another person at price $ 139.41 per share. | 14 Mar 2024 | 20,000 | 0 (0%) | 0% | 139.4 | 2,788,278 | Common Stock |
| George J. Morrow | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 39.79 per share. | 14 Mar 2024 | 20,000 | 20,000 (0%) | 0% | 39.8 | 795,800 | Common Stock |
| George J. Morrow | Director | Sale of securities on an exchange or to another person at price $ 139.42 per share. | 14 Mar 2024 | 20,000 | 0 (0%) | 0% | 139.4 | 2,788,432 | Common Stock |
| George J. Morrow | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 39.79 per share. | 14 Mar 2024 | 20,000 | 20,000 (0%) | 0% | 39.8 | 795,800 | Common Stock |
| George J. Morrow | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 14 Mar 2024 | 20,000 | 0 | - | - | Non-Qualified Stock Option | |
| George J. Morrow | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 14 Mar 2024 | 20,000 | 20,000 | - | - | Non-Qualified Stock Option | |
| Eric S. Benevich | Chief Commercial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 79.02 per share. | 14 Mar 2024 | 5,479 | 46,257 (0%) | 0% | 79.0 | 432,951 | Common Stock |
| Eric S. Benevich | Chief Commercial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 14 Mar 2024 | 5,479 | 33,881 | - | - | Non-Qualified Stock Option | |
| Eric S. Benevich | Chief Commercial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 14 Mar 2024 | 69,521 | 12,587 | - | - | Non-Qualified Stock Option | |
| Eric S. Benevich | Chief Commercial Officer | Sale of securities on an exchange or to another person at price $ 139.38 per share. | 14 Mar 2024 | 69,521 | 40,778 (0%) | 0% | 139.4 | 9,689,761 | Common Stock |
| Eric S. Benevich | Chief Commercial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 81.05 per share. | 14 Mar 2024 | 69,521 | 110,299 (0%) | 0% | 81.0 | 5,634,677 | Common Stock |
| Eric S. Benevich | Chief Commercial Officer | Sale of securities on an exchange or to another person at price $ 139.38 per share. | 14 Mar 2024 | 5,479 | 40,778 (0%) | 0% | 139.4 | 763,657 | Common Stock |
| Richard F. Pops | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 42.76 per share. | 13 Mar 2024 | 23,200 | 52,712 (0%) | 0% | 42.8 | 992,032 | Common Stock |
| Richard F. Pops | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 13 Mar 2024 | 23,200 | 0 | - | - | Non-Qualified Stock Option | |
| Richard F. Pops | Director | Sale of securities on an exchange or to another person at price $ 140.33 per share. | 13 Mar 2024 | 23,200 | 29,512 (0%) | 0% | 140.3 | 3,255,621 | Common Stock |
| Ingrid Delaet | Chief Regulatory Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 13 Mar 2024 | 3,000 | 4,367 | - | - | Non-Qualified Stock Option | |
| Ingrid Delaet | Chief Regulatory Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 106.02 per share. | 13 Mar 2024 | 3,000 | 10,507 (0%) | 0% | 106.0 | 318,060 | Common Stock |
| Ingrid Delaet | Chief Regulatory Officer | Sale of securities on an exchange or to another person at price $ 140.14 per share. | 13 Mar 2024 | 3,000 | 7,507 (0%) | 0% | 140.1 | 420,419 | Common Stock |
| Richard F. Pops | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 42.76 per share. | 08 Mar 2024 | 1,700 | 31,212 (0%) | 0% | 42.8 | 72,692 | Common Stock |
| Richard F. Pops | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 08 Mar 2024 | 100 | 23,200 | - | - | Non-Qualified Stock Option | |
| Richard F. Pops | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 08 Mar 2024 | 1,700 | 23,300 | - | - | Non-Qualified Stock Option | |
| Richard F. Pops | Director | Sale of securities on an exchange or to another person at price $ 140.00 per share. | 08 Mar 2024 | 100 | 29,512 (0%) | 0% | 140 | 14,000 | Common Stock |
| Richard F. Pops | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 42.76 per share. | 08 Mar 2024 | 100 | 29,612 (0%) | 0% | 42.8 | 4,276 | Common Stock |
| Richard F. Pops | Director | Sale of securities on an exchange or to another person at price $ 140.05 per share. | 08 Mar 2024 | 1,700 | 29,512 (0%) | 0% | 140.0 | 238,078 | Common Stock |
| Ingrid Delaet | Chief Regulatory Officer | Sale of securities on an exchange or to another person at price $ 140.03 per share. | 08 Mar 2024 | 1,800 | 7,507 (0%) | 0% | 140.0 | 252,053 | Common Stock |
| Ingrid Delaet | Chief Regulatory Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 08 Mar 2024 | 200 | 7,367 | - | - | Non-Qualified Stock Option | |
| Ingrid Delaet | Chief Regulatory Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 08 Mar 2024 | 1,800 | 7,567 | - | - | Non-Qualified Stock Option | |
| Ingrid Delaet | Chief Regulatory Officer | Sale of securities on an exchange or to another person at price $ 140.00 per share. | 08 Mar 2024 | 200 | 7,507 (0%) | 0% | 140 | 28,000 | Common Stock |
| Ingrid Delaet | Chief Regulatory Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 106.02 per share. | 08 Mar 2024 | 200 | 7,707 (0%) | 0% | 106.0 | 21,204 | Common Stock |
| Ingrid Delaet | Chief Regulatory Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 106.02 per share. | 08 Mar 2024 | 1,800 | 9,307 (0%) | 0% | 106.0 | 190,836 | Common Stock |
| Delaet Ingrid | Chief Regulatory Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 28 Feb 2024 | 2,500 | 9,761 | - | - | Non-Qualified Stock Option | |
| Eric S. Benevich | Chief Commercial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 28 Feb 2024 | 21,857 | 39,360 | - | - | Non-Qualified Stock Option | |
| Ingrid Delaet | Chief Regulatory Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 79.02 per share. | 28 Feb 2024 | 273 | 7,780 (0%) | 0% | 79.0 | 21,572 | Common Stock |
| Delaet Ingrid | Chief Regulatory Officer | Sale of securities on an exchange or to another person at price $ 135.64 per share. | 28 Feb 2024 | 2,500 | 7,507 (0%) | 0% | 135.6 | 339,104 | Common Stock |
| Ingrid Delaet | Chief Regulatory Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 79.02 per share. | 28 Feb 2024 | 2,500 | 10,007 (0%) | 0% | 79.0 | 197,550 | Common Stock |
| Delaet Ingrid | Chief Regulatory Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 79.02 per share. | 28 Feb 2024 | 2,500 | 10,007 (0%) | 0% | 79.0 | 197,550 | Common Stock |
| Delaet Ingrid | Chief Regulatory Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 28 Feb 2024 | 273 | 5,444 | - | - | Non-Qualified Stock Option | |
| Eric Benevich S. | Chief Commercial Officer | Sale of securities on an exchange or to another person at price $ 134.69 per share. | 28 Feb 2024 | 21,857 | 40,616 (0%) | 0% | 134.7 | 2,943,878 | Common Stock |
| S. Benevich Eric | Chief Commercial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 43.24 per share. | 28 Feb 2024 | 53,143 | 93,759 (0%) | 0% | 43.2 | 2,297,903 | Common Stock |
| Benevich S. Eric | Chief Commercial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 28 Feb 2024 | 53,143 | 0 | - | - | Non-Qualified Stock Option | |
| Eric Benevich S. | Chief Commercial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 79.02 per share. | 28 Feb 2024 | 21,857 | 62,473 (0%) | 0% | 79.0 | 1,727,140 | Common Stock |
| Delaet Ingrid | Chief Regulatory Officer | Sale of securities on an exchange or to another person at price $ 134.62 per share. | 28 Feb 2024 | 2,500 | 7,507 (0%) | 0% | 134.6 | 336,550 | Common Stock |
| Ingrid Delaet | Chief Regulatory Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 28 Feb 2024 | 1,544 | 5,717 | - | - | Non-Qualified Stock Option | |
| Ingrid Delaet | Chief Regulatory Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 79.02 per share. | 28 Feb 2024 | 1,544 | 9,051 (0%) | 0% | 79.0 | 122,007 | Common Stock |
| Delaet Ingrid | Chief Regulatory Officer | Sale of securities on an exchange or to another person at price $ 135.51 per share. | 28 Feb 2024 | 273 | 7,507 (0%) | 0% | 135.5 | 36,994 | Common Stock |
| S. Eric Benevich | Chief Commercial Officer | Sale of securities on an exchange or to another person at price $ 134.69 per share. | 28 Feb 2024 | 53,143 | 40,616 (0%) | 0% | 134.7 | 7,157,730 | Common Stock |
| Delaet Ingrid | Chief Regulatory Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 28 Feb 2024 | 2,500 | 7,261 | - | - | Non-Qualified Stock Option | |
| Ingrid Delaet | Chief Regulatory Officer | Sale of securities on an exchange or to another person at price $ 136.00 per share. | 28 Feb 2024 | 1,544 | 7,507 (0%) | 0% | 136 | 209,984 | Common Stock |
| V. Leslie Norwalk | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 84.95 per share. | 27 Feb 2024 | 8,000 | 8,000 (0%) | 0% | 85.0 | 679,600 | Common Stock |
| Leslie Norwalk V. | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 27 Feb 2024 | 8,000 | 1,724 | - | - | Non-Qualified Stock Option | |
| Norwalk V. Leslie | Director | Sale of securities on an exchange or to another person at price $ 135.67 per share. | 27 Feb 2024 | 8,000 | 0 (0%) | 0% | 135.7 | 1,085,388 | Common Stock |
| F. Richard Pops | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 20 Feb 2024 | 15,000 | 0 | - | - | Non-Qualified Stock Option | |
| F. Richard Pops | Director | Sale of securities on an exchange or to another person at price $ 132.47 per share. | 20 Feb 2024 | 15,000 | 29,512 (0%) | 0% | 132.5 | 1,987,047 | Common Stock |
| Pops Richard F. | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 12.98 per share. | 20 Feb 2024 | 15,000 | 44,512 (0%) | 0% | 13.0 | 194,700 | Common Stock |
| C. Kevin Gorman | Director, Chief Executive Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 13 Feb 2024 | 22,415 | 22,415 | - | - | Restricted Stock Unit | |
| Abernethy C. Matthew | Chief Financial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 13 Feb 2024 | 8,966 | 8,966 | - | - | Restricted Stock Unit | |
| Jude Onyia | Chief Scientific Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 13 Feb 2024 | 10,760 | 10,760 | - | - | Restricted Stock Unit | |
| Eric S. Benevich | Chief Commercial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 13 Feb 2024 | 39,426 | 39,426 | - | - | Stock Option | |
| Gorman Kevin C. | Director, Chief Executive Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 43.24 per share. | 13 Feb 2024 | 2,312 | 512,052 (0%) | 0% | 43.2 | 99,971 | Common Stock |
| Darin Lippoldt M. | Chief Legal Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 13 Feb 2024 | 8,070 | 8,070 | - | - | Restricted Stock Unit | |
| C. Gorman Kevin | Director, Chief Executive Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 35.99 per share. | 13 Feb 2024 | 2,778 | 509,740 (0%) | 0% | 36.0 | 99,980 | Common Stock |
| W. David Boyer | Chief Corp. Affairs Officer | Sale of securities on an exchange or to another person at price $ 133.05 per share. | 13 Feb 2024 | 856 | 4,895 (0%) | 0% | 133.0 | 113,889 | Common Stock |
| Gorman C. Kevin | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 133.02 per share. | 13 Feb 2024 | 2,832 | 514,596 (0%) | 0% | 133.0 | 376,700 | Common Stock |
| Kyle Gano W. | Chief Business Development Off | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 13 Feb 2024 | 8,966 | 8,966 | - | - | Restricted Stock Unit | |
| W. David Boyer | Chief Corp. Affairs Officer | Sale of securities on an exchange or to another person at price $ 133.10 per share. | 13 Feb 2024 | 955 | 5,751 (0%) | 0% | 133.1 | 127,106 | Common Stock |
| S. Julie Cooke | Chief Human Resources Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 13 Feb 2024 | 28,161 | 28,161 | - | - | Stock Option | |
| Onyia Jude | Chief Scientific Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 13 Feb 2024 | 54,069 | 54,069 | - | - | Stock Option | |
| Onyia Jude | Chief Scientific Officer | Sale of securities on an exchange or to another person at price $ 132.94 per share. | 13 Feb 2024 | 1,432 | 13,128 (0%) | 0% | 132.9 | 190,371 | Common Stock |
| Ingrid Delaet | Chief Regulatory Officer | Sale of securities on an exchange or to another person at price $ 133.03 per share. | 13 Feb 2024 | 716 | 7,507 (0%) | 0% | 133.0 | 95,253 | Common Stock |
| C. Abernethy Matthew | Chief Financial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 13 Feb 2024 | 45,058 | 45,058 | - | - | Stock Option | |
| Eiry W. Roberts | Chief Medical Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 13 Feb 2024 | 22,529 | 22,529 | - | - | Stock Option | |
| David Boyer W. | Chief Corp. Affairs Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 13 Feb 2024 | 30,977 | 30,977 | - | - | Stock Option | |
| Boyer W. David | Chief Corp. Affairs Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 13 Feb 2024 | 6,165 | 6,165 | - | - | Restricted Stock Unit | |
| W. Kyle Gano | Chief Business Development Off | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 13 Feb 2024 | 45,058 | 45,058 | - | - | Stock Option | |
| S. Benevich Eric | Chief Commercial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 13 Feb 2024 | 7,846 | 7,846 | - | - | Restricted Stock Unit | |
| Kevin Gorman C. | Director, Chief Executive Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 13 Feb 2024 | 112,644 | 112,644 | - | - | Stock Option | |
| Darin Lippoldt M. | Chief Legal Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 13 Feb 2024 | 40,552 | 40,552 | - | - | Stock Option | |
| Roberts Eiry W. | Chief Medical Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 13 Feb 2024 | 4,483 | 4,483 | - | - | Restricted Stock Unit | |
| Roberts W. Eiry | Chief Medical Officer | Sale of securities on an exchange or to another person at price $ 132.96 per share. | 13 Feb 2024 | 1,114 | 23,716 (0%) | 0% | 133.0 | 148,122 | Common Stock |
| Abernethy Matthew C. | Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 132.85 per share. | 13 Feb 2024 | 1,352 | 31,528 (0%) | 0% | 132.8 | 179,612 | Common Stock |
| Cooke S. Julie | Chief Human Resources Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 13 Feb 2024 | 5,604 | 5,604 | - | - | Restricted Stock Unit | |
| Cooke S. Julie | Chief Human Resources Officer | Sale of securities on an exchange or to another person at price $ 133.04 per share. | 13 Feb 2024 | 796 | 17,976 (0%) | 0% | 133.0 | 105,902 | Common Stock |
| Benevich Eric S. | Chief Commercial Officer | Sale of securities on an exchange or to another person at price $ 133.01 per share. | 13 Feb 2024 | 1,098 | 40,616 (0%) | 0% | 133.0 | 146,050 | Common Stock |
| Lippoldt M. Darin | Chief Legal Officer | Sale of securities on an exchange or to another person at price $ 132.99 per share. | 13 Feb 2024 | 1,098 | 39,740 (0%) | 0% | 133.0 | 146,028 | Common Stock |
| Kevin Gorman C. | Director, Chief Executive Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 13 Feb 2024 | 2,312 | 0 | - | - | Incentive Stock Option | |
| Ingrid Delaet | Chief Regulatory Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 13 Feb 2024 | 5,604 | 5,604 | - | - | Restricted Stock Unit | |
| Kevin Gorman C. | Director, Chief Executive Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 13 Feb 2024 | 2,778 | 0 | - | - | Incentive Stock Option | |
| Kyle W. Gano | Chief Business Development Off | Sale of securities on an exchange or to another person at price $ 132.89 per share. | 13 Feb 2024 | 1,352 | 135,166 (0%) | 0% | 132.9 | 179,674 | Common Stock |
| Ingrid Delaet | Chief Regulatory Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 13 Feb 2024 | 28,161 | 28,161 | - | - | Stock Option | |
| Benevich Eric S. | Chief Commercial Officer | Sale of securities on an exchange or to another person at price $ 134.19 per share. | 06 Feb 2024 | 980 | 39,631 (0%) | 0% | 134.2 | 131,509 | Common Stock |
| Kyle Gano W. | Chief Business Development Off | Sale of securities on an exchange or to another person at price $ 142.20 per share. | 06 Feb 2024 | 1,600 | 133,072 (0%) | 0% | 142.2 | 227,522 | Common Stock |
| Cooke Julie S. | Chief Human Resources Officer | Sale of securities on an exchange or to another person at price $ 136.78 per share. | 06 Feb 2024 | 629 | 17,263 (0%) | 0% | 136.8 | 86,035 | Common Stock |
| C. Abernethy Matthew | Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 134.21 per share. | 06 Feb 2024 | 980 | 30,314 (0%) | 0% | 134.2 | 131,529 | Common Stock |
| W. Roberts Eiry | Chief Medical Officer | Sale of securities on an exchange or to another person at price $ 134.21 per share. | 06 Feb 2024 | 980 | 22,717 (0%) | 0% | 134.2 | 131,522 | Common Stock |
| Lippoldt Darin M. | Chief Legal Officer | Sale of securities on an exchange or to another person at price $ 142.17 per share. | 06 Feb 2024 | 1,041 | 37,939 (0%) | 0% | 142.2 | 147,995 | Common Stock |
| Eric Benevich S. | Chief Commercial Officer | Sale of securities on an exchange or to another person at price $ 142.12 per share. | 06 Feb 2024 | 1,280 | 38,751 (0%) | 0% | 142.1 | 181,910 | Common Stock |
| David W. Boyer | Chief Corp. Affairs Officer | Sale of securities on an exchange or to another person at price $ 141.96 per share. | 06 Feb 2024 | 216 | 4,894 (0%) | 0% | 142.0 | 30,663 | Common Stock |
| Gorman Kevin C. | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 142.18 per share. | 06 Feb 2024 | 3,040 | 504,919 (0%) | 0% | 142.2 | 432,218 | Common Stock |
| Cooke S. Julie | Chief Human Resources Officer | Sale of securities on an exchange or to another person at price $ 142.17 per share. | 06 Feb 2024 | 640 | 17,838 (0%) | 0% | 142.2 | 90,990 | Common Stock |
| Abernethy C. Matthew | Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 142.19 per share. | 06 Feb 2024 | 1,280 | 29,434 (0%) | 0% | 142.2 | 182,000 | Common Stock |
| David W. Boyer | Chief Corp. Affairs Officer | Sale of securities on an exchange or to another person at price $ 136.78 per share. | 06 Feb 2024 | 628 | 4,895 (0%) | 0% | 136.8 | 85,898 | Common Stock |
| W. Roberts Eiry | Chief Medical Officer | Sale of securities on an exchange or to another person at price $ 142.24 per share. | 06 Feb 2024 | 1,121 | 21,837 (0%) | 0% | 142.2 | 159,446 | Common Stock |
| Lippoldt Darin M. | Chief Legal Officer | Sale of securities on an exchange or to another person at price $ 134.24 per share. | 06 Feb 2024 | 911 | 38,755 (0%) | 0% | 134.2 | 122,289 | Common Stock |
| Julie Cooke S. | Chief Human Resources Officer | Sale of securities on an exchange or to another person at price $ 134.23 per share. | 06 Feb 2024 | 700 | 17,892 (0%) | 0% | 134.2 | 93,961 | Common Stock |
| Cooke S. Julie | Chief Human Resources Officer | Sale of securities on an exchange or to another person at price $ 141.96 per share. | 06 Feb 2024 | 575 | 17,263 (0%) | 0% | 142.0 | 81,627 | Common Stock |
| W. David Boyer | Chief Corp. Affairs Officer | Sale of securities on an exchange or to another person at price $ 134.19 per share. | 06 Feb 2024 | 700 | 5,523 (0%) | 0% | 134.2 | 93,932 | Common Stock |
| Boyer David W. | Chief Corp. Affairs Officer | Sale of securities on an exchange or to another person at price $ 141.96 per share. | 06 Feb 2024 | 240 | 5,110 (0%) | 0% | 142.0 | 34,070 | Common Stock |
| Kyle W. Gano | Chief Business Development Off | Sale of securities on an exchange or to another person at price $ 134.20 per share. | 06 Feb 2024 | 980 | 133,952 (0%) | 0% | 134.2 | 131,519 | Common Stock |
| C. Kevin Gorman | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 134.15 per share. | 06 Feb 2024 | 2,274 | 506,962 (0%) | 0% | 134.1 | 305,052 | Common Stock |
| W. David Boyer | Chief Corp. Affairs Officer | Sale of securities on an exchange or to another person at price $ 140.87 per share. | 31 Jan 2024 | 1,104 | 5,886 (0%) | 0% | 140.9 | 155,524 | Common Stock |
| Kevin Gorman C. | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 140.69 per share. | 31 Jan 2024 | 2,707 | 502,188 (0%) | 0% | 140.7 | 380,845 | Common Stock |
| Gano Kyle W. | Chief Business Development Off | Sale of securities on an exchange or to another person at price $ 140.70 per share. | 31 Jan 2024 | 1,541 | 131,635 (0%) | 0% | 140.7 | 216,813 | Common Stock |
| Darin Lippoldt M. | Chief Legal Officer | Sale of securities on an exchange or to another person at price $ 140.65 per share. | 31 Jan 2024 | 1,250 | 37,005 (0%) | 0% | 140.6 | 175,810 | Common Stock |
| Boyer W. David | Chief Corp. Affairs Officer | Sale of securities on an exchange or to another person at price $ 140.72 per share. | 31 Jan 2024 | 992 | 4,894 (0%) | 0% | 140.7 | 139,591 | Common Stock |
| Eric Benevich S. | Chief Commercial Officer | Sale of securities on an exchange or to another person at price $ 140.78 per share. | 31 Jan 2024 | 1,207 | 37,601 (0%) | 0% | 140.8 | 169,927 | Common Stock |
| Abernethy Matthew C. | Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 140.72 per share. | 31 Jan 2024 | 1,283 | 28,284 (0%) | 0% | 140.7 | 180,539 | Common Stock |
| Jude Onyia | Chief Scientific Officer | Sale of securities on an exchange or to another person at price $ 141.94 per share. | 31 Jan 2024 | 126 | 11,843 (0%) | 0% | 141.9 | 17,884 | Common Stock |
| S. Julie Cooke | Chief Human Resources Officer | Sale of securities on an exchange or to another person at price $ 140.70 per share. | 31 Jan 2024 | 916 | 18,087 (0%) | 0% | 140.7 | 128,883 | Common Stock |
| Eiry W. Roberts | Chief Medical Officer | Sale of securities on an exchange or to another person at price $ 140.79 per share. | 31 Jan 2024 | 1,457 | 20,832 (0%) | 0% | 140.8 | 205,132 | Common Stock |
| S. Julie Cooke | Chief Human Resources Officer | Sale of securities on an exchange or to another person at price $ 141.94 per share. | 31 Jan 2024 | 824 | 17,263 (0%) | 0% | 141.9 | 116,959 | Common Stock |
| Ingrid Delaet | Chief Regulatory Officer | Sale of securities on an exchange or to another person at price $ 141.94 per share. | 31 Jan 2024 | 422 | 6,309 (0%) | 0% | 141.9 | 59,899 | Common Stock |
| Ingrid Delaet | Chief Regulatory Officer | Sale of securities on an exchange or to another person at price $ 139.77 per share. | 31 Jan 2024 | 623 | 6,865 (0%) | 0% | 139.8 | 87,077 | Common Stock |
| M. Lippoldt Darin | Chief Legal Officer | Sale of securities on an exchange or to another person at price $ 139.86 per share. | 22 Jan 2024 | 10,000 | 35,882 (0%) | 0% | 139.9 | 1,398,553 | Common Stock |
| M. Darin Lippoldt | Chief Legal Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 79.02 per share. | 22 Jan 2024 | 10,000 | 45,882 (0%) | 0% | 79.0 | 790,200 | Common Stock |
| Lippoldt M. Darin | Chief Legal Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 22 Jan 2024 | 10,000 | 53,372 | - | - | Non-Qualified Stock Option | |
| Kevin Gorman C. | Director, Chief Executive Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 19.59 per share. | 08 Jan 2024 | 62,023 | 561,777 (0%) | 0% | 19.6 | 1,215,031 | Common Stock |
| Kevin Gorman C. | Director, Chief Executive Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 08 Jan 2024 | 105,835 | 62,023 | - | - | Non-Qualified Stock Option | |
| Kevin Gorman C. | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 134.01 per share. | 08 Jan 2024 | 62,023 | 499,754 (0%) | 0% | 134.0 | 8,311,895 | Common Stock |
| Kevin Gorman C. | Director, Chief Executive Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 08 Jan 2024 | 62,023 | 0 | - | - | Non-Qualified Stock Option | |
| Kevin C. Gorman | Director, Chief Executive Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 19.59 per share. | 08 Jan 2024 | 105,835 | 605,589 (0%) | 0% | 19.6 | 2,073,308 | Common Stock |
| Kevin Gorman C. | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 132.44 per share. | 08 Jan 2024 | 105,835 | 499,754 (0%) | 0% | 132.4 | 14,016,523 | Common Stock |
| Gano Kyle W. | Chief Business Development Off | Exercise or conversion of derivative security received from the company (such as an option) at price $ 19.59 per share. | 02 Jan 2024 | 68,884 | 199,134 (0%) | 0% | 19.6 | 1,349,438 | Common Stock |
| Kyle W. Gano | Chief Business Development Off | Sale of securities on an exchange or to another person at price $ 131.47 per share. | 02 Jan 2024 | 68,884 | 130,250 (0%) | 0% | 131.5 | 9,056,290 | Common Stock |
| Gano W. Kyle | Chief Business Development Off | Sale of securities on an exchange or to another person at price $ 131.44 per share. | 02 Jan 2024 | 6,116 | 130,250 (0%) | 0% | 131.4 | 803,905 | Common Stock |
| William Rastetter H. | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 12.98 per share. | 02 Jan 2024 | 20,000 | 62,785 (0%) | 0% | 13.0 | 259,600 | Common Stock |
| William H. Rastetter | Director | Sale of securities on an exchange or to another person at price $ 131.47 per share. | 02 Jan 2024 | 11,044 | 51,741 (0%) | 0% | 131.5 | 1,451,927 | Common Stock |
| Rastetter H. William | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 02 Jan 2024 | 20,000 | 0 | - | - | Non-Qualified Stock Option | |
| W. Kyle Gano | Chief Business Development Off | Exercise or conversion of derivative security received from the company (such as an option) at price $ 19.59 per share. | 02 Jan 2024 | 6,116 | 136,366 (0%) | 0% | 19.6 | 119,812 | Common Stock |
| W. Gano Kyle | Chief Business Development Off | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 02 Jan 2024 | 68,884 | 0 | - | - | Non-Qualified Stock Option | |
| Gano Kyle W. | Chief Business Development Off | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 02 Jan 2024 | 6,116 | 0 | - | - | Incentive Stock Option | |
| Julie S. Cooke | Chief Human Resources Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 81.05 per share. | 22 Dec 2023 | 14,000 | 31,263 (0%) | 0% | 81.1 | 1,134,700 | Common Stock |
| S. Julie Cooke | Chief Human Resources Officer | Sale of securities on an exchange or to another person at price $ 126.79 per share. | 22 Dec 2023 | 10,000 | 17,263 (0%) | 0% | 126.8 | 1,267,945 | Common Stock |
| Julie S. Cooke | Chief Human Resources Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 22 Dec 2023 | 14,000 | 8,129 | - | - | Non-Qualified Stock Option | |
| Cooke Julie S. | Chief Human Resources Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 61.82 per share. | 22 Dec 2023 | 10,000 | 27,263 (0%) | 0% | 61.8 | 618,200 | Common Stock |
| W. Eiry Roberts | Chief Medical Officer | Sale of securities on an exchange or to another person at price $ 126.74 per share. | 22 Dec 2023 | 10,000 | 19,521 (0%) | 0% | 126.7 | 1,267,448 | Common Stock |
| S. Cooke Julie | Chief Human Resources Officer | Sale of securities on an exchange or to another person at price $ 129.99 per share. | 22 Dec 2023 | 14,000 | 17,263 (0%) | 0% | 130.0 | 1,819,863 | Common Stock |
| Gary Lyons A. | Director | Sale of securities on an exchange or to another person at price $ 130.04 per share. | 22 Dec 2023 | 10,000 | 193,697 (0%) | 0% | 130.0 | 1,300,443 | Common Stock |
| Julie Cooke S. | Chief Human Resources Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 22 Dec 2023 | 10,000 | 23,532 | - | - | Non-Qualified Stock Option | |
| Roberts W. Eiry | Chief Medical Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 12 Dec 2023 | 6,978 | 46,387 | - | - | Non-Qualified Stock Option | |
| Eiry W. Roberts | Chief Medical Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 81.05 per share. | 12 Dec 2023 | 6,947 | 36,468 (0%) | 0% | 81.0 | 563,054 | Common Stock |
| W. Eiry Roberts | Chief Medical Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 81.05 per share. | 12 Dec 2023 | 6,978 | 36,499 (0%) | 0% | 81.1 | 565,567 | Common Stock |
| Eiry W. Roberts | Chief Medical Officer | Sale of securities on an exchange or to another person at price $ 120.30 per share. | 12 Dec 2023 | 6,978 | 29,521 (0%) | 0% | 120.3 | 839,461 | Common Stock |
| Eiry Roberts W. | Chief Medical Officer | Sale of securities on an exchange or to another person at price $ 120.31 per share. | 12 Dec 2023 | 6,947 | 29,521 (0%) | 0% | 120.3 | 835,779 | Common Stock |
| Roberts W. Eiry | Chief Medical Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 12 Dec 2023 | 6,947 | 39,440 | - | - | Non-Qualified Stock Option | |
| W. Roberts Eiry | Chief Medical Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 07 Dec 2023 | 38,722 | 12,742 | - | - | Non-Qualified Stock Option | |
| Roberts Eiry W. | Chief Medical Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 81.05 per share. | 07 Dec 2023 | 11,775 | 41,296 (0%) | 0% | 81.1 | 954,364 | Common Stock |
| W. Roberts Eiry | Chief Medical Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 79.02 per share. | 07 Dec 2023 | 14,140 | 43,661 (0%) | 0% | 79.0 | 1,117,343 | Common Stock |
| Eiry W. Roberts | Chief Medical Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 77.81 per share. | 07 Dec 2023 | 12,742 | 42,263 (0%) | 0% | 77.8 | 991,455 | Common Stock |
| W. Eiry Roberts | Chief Medical Officer | Sale of securities on an exchange or to another person at price $ 120.37 per share. | 07 Dec 2023 | 14,140 | 29,521 (0%) | 0% | 120.4 | 1,702,053 | Common Stock |
| Eiry Roberts W. | Chief Medical Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 77.81 per share. | 07 Dec 2023 | 38,722 | 68,243 (0%) | 0% | 77.8 | 3,012,959 | Common Stock |
| W. Roberts Eiry | Chief Medical Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 07 Dec 2023 | 11,775 | 53,665 | - | - | Non-Qualified Stock Option | |
| Roberts Eiry W. | Chief Medical Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 07 Dec 2023 | 12,742 | 0 | - | - | Non-Qualified Stock Option | |
| Eiry W. Roberts | Chief Medical Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 81.05 per share. | 07 Dec 2023 | 100 | 29,621 (0%) | 0% | 81.1 | 8,105 | Common Stock |
| Eiry Roberts W. | Chief Medical Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 81.05 per share. | 07 Dec 2023 | 200 | 29,721 (0%) | 0% | 81.1 | 16,210 | Common Stock |
| Roberts Eiry W. | Chief Medical Officer | Sale of securities on an exchange or to another person at price $ 120.37 per share. | 07 Dec 2023 | 38,722 | 29,521 (0%) | 0% | 120.4 | 4,661,118 | Common Stock |
| Eiry Roberts W. | Chief Medical Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 07 Dec 2023 | 100 | 53,365 | - | - | Non-Qualified Stock Option | |
| Roberts W. Eiry | Chief Medical Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 07 Dec 2023 | 200 | 53,465 | - | - | Non-Qualified Stock Option | |
| Roberts Eiry W. | Chief Medical Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 07 Dec 2023 | 14,140 | 60,005 | - | - | Non-Qualified Stock Option | |
| Eiry W. Roberts | Chief Medical Officer | Sale of securities on an exchange or to another person at price $ 120.37 per share. | 07 Dec 2023 | 12,742 | 29,521 (0%) | 0% | 120.4 | 1,533,774 | Common Stock |
| W. Eiry Roberts | Chief Medical Officer | Sale of securities on an exchange or to another person at price $ 120.37 per share. | 07 Dec 2023 | 11,775 | 29,521 (0%) | 0% | 120.4 | 1,417,374 | Common Stock |
| Eiry W. Roberts | Chief Medical Officer | Sale of securities on an exchange or to another person at price $ 120.00 per share. | 07 Dec 2023 | 100 | 29,521 (0%) | 0% | 120 | 12,000 | Common Stock |
| Eiry W. Roberts | Chief Medical Officer | Sale of securities on an exchange or to another person at price $ 120.16 per share. | 07 Dec 2023 | 200 | 29,521 (0%) | 0% | 120.2 | 24,031 | Common Stock |
| Darin M. Lippoldt | Chief Legal Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 43.24 per share. | 06 Dec 2023 | 20,830 | 56,712 (0%) | 0% | 43.2 | 900,689 | Common Stock |
| Lippoldt Darin M. | Chief Legal Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 06 Dec 2023 | 20,830 | 4,376 | - | - | Non-Qualified Stock Option | |
| Eiry W. Roberts | Chief Medical Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 06 Dec 2023 | 8,396 | 51,464 | - | - | Non-Qualified Stock Option | |
| M. Darin Lippoldt | Chief Legal Officer | Sale of securities on an exchange or to another person at price $ 119.86 per share. | 06 Dec 2023 | 20,830 | 35,882 (0%) | 0% | 119.9 | 2,496,648 | Common Stock |
| Eiry W. Roberts | Chief Medical Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 77.81 per share. | 06 Dec 2023 | 8,396 | 37,917 (0%) | 0% | 77.8 | 653,293 | Common Stock |
| W. Roberts Eiry | Chief Medical Officer | Sale of securities on an exchange or to another person at price $ 120.03 per share. | 06 Dec 2023 | 8,396 | 29,521 (0%) | 0% | 120.0 | 1,007,780 | Common Stock |
| Gary Lyons A. | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 12.98 per share. | 01 Dec 2023 | 5,000 | 208,697 (0%) | 0% | 13.0 | 64,900 | Common Stock |
| A. Lyons Gary | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 01 Dec 2023 | 5,000 | 0 | - | - | Non-Qualified Stock Option | |
| A. Gary Lyons | Director | Sale of securities on an exchange or to another person at price $ 116.77 per share. | 01 Dec 2023 | 5,000 | 203,697 (0%) | 0% | 116.8 | 583,837 | Common Stock |
| Ingrid Delaet | Chief Regulatory Officer | Sale of securities on an exchange or to another person at price $ 107.52 per share. | 28 Aug 2023 | 1,431 | 5,931 (0%) | 0% | 107.5 | 153,861 | Common Stock |
| Kevin C. Gorman | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 107.40 per share. | 21 Aug 2023 | 9,328 | 499,754 (0%) | 0% | 107.4 | 1,001,816 | Common Stock |
| Eric S. Benevich | Chief Commercial Officer | Sale of securities on an exchange or to another person at price $ 107.40 per share. | 21 Aug 2023 | 1,600 | 36,436 (0%) | 0% | 107.4 | 171,836 | Common Stock |
| Darin M. Lippoldt | Chief Legal Officer | Sale of securities on an exchange or to another person at price $ 107.39 per share. | 21 Aug 2023 | 2,132 | 46,991 (0%) | 0% | 107.4 | 228,951 | Common Stock |
| Kyle W. Gano | Chief Business Development Off | Sale of securities on an exchange or to another person at price $ 107.41 per share. | 21 Aug 2023 | 2,132 | 130,250 (0%) | 0% | 107.4 | 228,993 | Common Stock |
| Matthew C. Abernethy | Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 107.39 per share. | 21 Aug 2023 | 2,132 | 27,131 (0%) | 0% | 107.4 | 228,958 | Common Stock |
| Eiry W. Roberts | Chief Medical Officer | Sale of securities on an exchange or to another person at price $ 107.38 per share. | 21 Aug 2023 | 3,198 | 29,521 (0%) | 0% | 107.4 | 343,388 | Common Stock |
| Julie S. Cooke | Chief Human Resources Officer | Sale of securities on an exchange or to another person at price $ 107.41 per share. | 21 Aug 2023 | 2,132 | 18,087 (0%) | 0% | 107.4 | 228,991 | Common Stock |
| David W. Boyer | Chief Corp. Affairs Officer | Sale of securities on an exchange or to another person at price $ 107.41 per share. | 21 Aug 2023 | 1,600 | 6,193 (0%) | 0% | 107.4 | 171,862 | Common Stock |
| Jude Onyia | Chief Scientific Officer | Sale of securities on an exchange or to another person at price $ 107.37 per share. | 21 Aug 2023 | 3,198 | 9,638 (0%) | 0% | 107.4 | 343,368 | Common Stock |
| Ingrid Delaet | Chief Regulatory Officer | Sale of securities on an exchange or to another person at price $ 107.42 per share. | 21 Aug 2023 | 1,404 | 4,645 (0%) | 0% | 107.4 | 150,820 | Common Stock |
| Christine A. Poon | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 11 Jul 2023 | 16,375 | 16,375 | - | - | Non-Qualified Stock Option | |
| Gary A. Lyons | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 17 May 2023 | 2,100 | 2,100 | - | - | Restricted Stock Unit | |
| Gary A. Lyons | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 17 May 2023 | 4,290 | 4,290 | - | - | Non-Qualified Stock Option | |
| Richard F. Pops | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 17 May 2023 | 4,199 | 4,199 | - | - | Restricted Stock Unit | |
| Shalini Sharp | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 17 May 2023 | 2,100 | 2,100 | - | - | Restricted Stock Unit | |
| Shalini Sharp | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 17 May 2023 | 4,290 | 4,290 | - | - | Non-Qualified Stock Option | |
| William H. Rastetter | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 17 May 2023 | 8,579 | 8,579 | - | - | Non-Qualified Stock Option | |
| George J. Morrow | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 17 May 2023 | 4,199 | 4,199 | - | - | Restricted Stock Unit | |
| Stephen A. Sherwin | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 17 May 2023 | 4,199 | 4,199 | - | - | Restricted Stock Unit | |
| Leslie V. Norwalk | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 17 May 2023 | 4,290 | 4,290 | - | - | Non-Qualified Stock Option | |
| Leslie V. Norwalk | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 17 May 2023 | 2,100 | 2,100 | - | - | Restricted Stock Unit | |
| Johanna Mercier | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 17 May 2023 | 2,100 | 2,100 | - | - | Restricted Stock Unit | |
| Johanna Mercier | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 17 May 2023 | 4,290 | 4,290 | - | - | Non-Qualified Stock Option | |
| William H. Rastetter | Director | Sale of securities on an exchange or to another person at price $ 101.43 per share. | 01 May 2023 | 4,300 | 42,785 (0%) | 0% | 101.4 | 436,135 | Common Stock |
| William H. Rastetter | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 01 May 2023 | 7,625 | 0 | - | - | Non-Qualified Stock Option | |
| William H. Rastetter | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 12.71 per share. | 01 May 2023 | 7,625 | 47,085 (0%) | 0% | 12.7 | 96,914 | Common Stock |
| Julie S. Cooke | Chief Human Resources Officer | Sale of securities on an exchange or to another person at price $ 103.89 per share. | 01 May 2023 | 11,397 | 16,169 (0%) | 0% | 103.9 | 1,184,049 | Common Stock |
| Julie S. Cooke | Chief Human Resources Officer | Sale of securities on an exchange or to another person at price $ 103.82 per share. | 25 Apr 2023 | 100 | 27,561 (0%) | 0% | 103.8 | 10,382 | Common Stock |
| Eiry W. Roberts | Chief Medical Officer | Sale of securities on an exchange or to another person at price $ 103.48 per share. | 24 Apr 2023 | 14,400 | 26,644 (0%) | 0% | 103.5 | 1,490,059 | Common Stock |
| William H. Rastetter | Director | Sale of securities on an exchange or to another person at price $ 105.04 per share. | 19 Apr 2023 | 6,034 | 39,460 (0%) | 0% | 105.0 | 633,787 | Common Stock |
| William H. Rastetter | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 12.71 per share. | 19 Apr 2023 | 10,765 | 45,494 (0%) | 0% | 12.7 | 136,823 | Common Stock |
| William H. Rastetter | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 12.71 per share. | 19 Apr 2023 | 1,610 | 35,632 (0%) | 0% | 12.7 | 20,463 | Common Stock |
| William H. Rastetter | Director | Sale of securities on an exchange or to another person at price $ 105.00 per share. | 19 Apr 2023 | 903 | 34,729 (0%) | 0% | 105.0 | 94,819 | Common Stock |
| William H. Rastetter | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 19 Apr 2023 | 10,765 | 7,625 | - | - | Non-Qualified Stock Option | |
| William H. Rastetter | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 19 Apr 2023 | 1,610 | 18,390 | - | - | Non-Qualified Stock Option | |
| Kevin C. Gorman | Director, Chief Executive Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 13 Feb 2023 | 133,656 | 133,656 | - | - | Stock Option | |
| Kevin C. Gorman | Director, Chief Executive Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 13 Feb 2023 | 21,506 | 21,506 | - | - | Restricted Stock Unit | |
| Eric S. Benevich | Chief Commercial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 13 Feb 2023 | 8,332 | 8,332 | - | - | Restricted Stock Unit |